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MR-guided focused ultrasound (MRgFUS) is a non-invasive brain treatment using MRI for precise targeting of brain areas causing tremors in Parkinson’s disease, focusing sound waves to heat and lesion abnormal tissue without surgery, offering immediate relief for tremor-dominant PD patients, often with rapid recovery and no implants. It’s a functional neurosurgical option for patients unresponsive to medication, targeting areas like the thalamus or pallidothalamic tract, providing a permanent lesion for symptom control.

How it works

• Targeting: MRI precisely maps the brain to identify the specific small area (like the thalamus or globus pallidus) responsible for abnormal signals causing tremor.
• Energy Delivery: 1000+ focused ultrasound beams converge at the target, creating heat to create a tiny lesion (ablation).
• Real-time Monitoring: MRI provides real-time temperature monitoring and allows immediate assessment of tremor reduction during the procedure.

Benefits

• Non-invasive: No incisions, drill holes, or implanted devices.
• No General Anesthesia: Usually performed with the patient awake, allowing for immediate feedback.
• Immediate Results: Tremor improvement is often seen during the treatment.
• Rapid Recovery: Patients often go home the same day.

Key Considerations

• For Tremor-Dominant PD: Primarily targets severe, medication-resistant tremors, not all Parkinson’s symptoms.
• Permanent Lesion: Creates a permanent change in brain tissue.
• Potential Side Effects: Can include headaches, dizziness, or balance issues, usually temporary.
• Skull Factors: The density of the skull can affect treatment.
• Unilateral vs. Bilateral: Often done on one side first (unilateral).

Who is a candidate?

• Patients with tremor-dominant Parkinson’s disease who don’t respond well to medication.
  Must be over 30 years old.
• Requires assessment by a neurologist and specialist team.